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Originally formed as an organized research unit of the University of California, San Diego in 1946 to bring university resources to bear on urgent WWII defense problems, today MPL continues its mission of research, engineering, and education. Scientific research and instrument development at the Marine Physical Laboratory is dedicated to the scientific understanding and application of knowledge for the ocean, its boundaries, and the surrounding media. MPL also reaffirms its traditional role of contributing technical leadership in ocean science and underwater technology to the scientific and research community.

Drawing on its own expertise and the traditional strengths of a major university, MPL provides innovative and imaginative solutions to complex technical problems. A large portion of the Laboratory's research program is devoted to exploratory and advanced development programs, with the remainder committed to basic research.

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